Bioinformatics analysis of the diagnostic significance and functions of RDH5 in breast cancer

Objective: RDH5 (Retinol dehydrogenase 5) is one of the member short-chain dehydrogenase/reductase (SDR) family and plays a critical role in variety tumor processes. In this study, we analyzed expression, diagnostic significance gene function breast cancer. Methods: The Gene Expression Profiling Interactive Analysis (GEPIA) database was used to determine prognostic value University Alabama at Birmingham (UALCAN) its expression different subtypes, clinical stages altered signal pathways Then explored co-expression cancer constructed corresponding network through cBioPortal database. String interactions with other proteins. Results: differentiated various tumours compared normal tissue, down-regulated tissue subtypes There no correlation between survival significantly associated parameters. Additionally, protein indicated it closely SWI-SNF (switching/sucrose non-fermenting) complex status mammalian Target Rapamycin (mTOR), WNT (Wingless/Integrated), MYC/MYCN (Myelocytomatosis oncogene/euroblastoma derived MYC), RTK (receptor Tyrosine kinases), p53/Rb (tumor p53/Retinoblastoma) pathways. Interaction analysis genes showed that main related functions were ethanol oxidation, regulation heart contraction negative necrosis factor. Lastly, Protein-protein interaction (PPI) most relevant Kyoto Encyclopedia Genes Genomes (KEGG) retinol metabolism, vitamin digestion absorption metabolic Conclusion: These results implied might be larvaceous biomarker for metabolism. However, more studies are needed confirm our findings support importance